ABSTRACT
As preventive, curative and restorative measures in modern conditions of the spread of infectious diseases (Covid 19), the use of sorption materials and detoxification methods with their use in hemosorption are of particular importance. It is known that hemosorption is an effective method of detoxification of the body, and no less important is the use of safe sorbents in relation to the shaped elements of blood, both time-tested sorbents and new, less studied, but more promising from the point of view of their safe production technology. The purpose of this work is to study with the help of scanning flow cytometry the effect of a sorbent with carbon nanofiber A1203@PDMS/CNF in comparison with a carbon-free sorbent A1203@PDMS on morphofunctional parameters erythrocytes. The study of the physico-chemical properties of sorbents was carried out according to standard methods. The biological properties of sorbents were evaluated by its effect on erythrocytes of erythrocyte concentrate during hemoperfusion of blood through columns with sorbents using the method of scanning flow cytometry according to the standard method. The data obtained using the method of scanning flow cytometry made it possible to conclude that the studied sorbents do not have a traumatic effect on the morphofunctional parameters of erythrocytes. The introduction of carbon nanofiber into the composition of the sorbent in an amount of 0.02% improves the functional parameters of blood erythrocytes both in comparison with the initial donor blood and compared to the sorbent without carbon. © 2022 IEEE.